Eye examination: with an eye care provider; if Keratoconjunctivitis Sicca symptoms are present for more than 3 months, a diagnosis of Sjögren’s Syndrome should be considered.1
Schirmer test: small piece of paper placed inside the eyelid to determine tear production quantity.1
Fluorescein staining/tear break up time (TBUT): Fluorescein dye is placed on the surface of the eye to determine how quickly the tears are breaking up/evaporating.
Lissamine green stain: Stain that targets devitalized cells while ensuring to leave healthy cells alone.3
Sjo® test: in-office blood test (finger-prick) that recognizes auto-antibody markers and other early biomarkers of Sjögren’s Syndrome.4
Biopsy of salivary and lacrimal glands: very small portion of gland removed to be assessed for the presence of inflammatory cells; gold standard for diagnosis.2,4
Serological tests: blood tests to determine levels of auto-antibody markers and rheumatoid factors.1
Parotid sialography or salivary gland scintigraphy: salivary gland imaging tests to determine how the salivary glands are functioning.1, 2